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The principal cytochrome P450 isoenzyme involved seems to get CYP2E1, with CYP1A2 and CYP3A4 as more pathways. Close to 85% of the oral dose seems inside the urine inside of 24 hrs of administration, most since the glucuronide conjugate, with smaller amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity information and facts.